SpyInfo
HOWARTH LAB
SOCIAL
ADDRESS
Department of Pharmacology,
University of Cambridge,
Tennis Court Road,
Cambridge
CB2 1PD
UK
CONTACT
e: mh2186@cam.ac.uk
t: 01223 334176
2025 Mark Howarth. All rights reserved.
Papers and Patents using Spy technology
Many of these publications don’t come up from a Pubmed search or citation search, so it should be useful
to bring them all together and hyperlinked (now >1,200 publications). Patents may be omitted if there is a journal
paper covering very similar work. Ones with particular relevance to
IMMUNOLOGY
,
MATERIALS
(polymers or
mechanobiology),
IMAGING
,
SEQUENCING
or
ENZYMES
are marked.
For an overview, please see our open-access review “
Power to the Protein
” from 2020.
SpyBank
is a database of >1,000 Tag/Catcher aa sequences to download (
Excel file
), from publications below.
SpyBank includes includes expression organism, Tag/Catcher location (N-terminal, internal, C-terminal) and
annotated linkers, as a reference for groups creating their own fusions. SpyBank itself is described in:
“Insider information on successful covalent
protein coupling with help from SpyBank.
Keeble AH, Howarth M. Meth Enz 2019
PDF
”.
(See note on codon usage at
Reagents
page).
Most recent below. Publications 601-900
here
. Publications 301-600
here
.
Publications 1-300
here
.
Engineering a Fusion Protein Biomaterial Based on SpyTag/SpyCatcher Bioconjugation of Elastin
and Collagen Synthetic Proteins
Pedro Toledo-Garcia…Alberto Donayre-Torres. ACS Omega April 16, 2025
MATERIALS
HETERODIMERIC PROTEIN PRODUCTION METHOD, DIMERIC PROTEIN, MONOMERIC PROTEIN, AND
TARGET RESPONSIVE HETERODIMERIC PROTEIN SCREENING METHOD
European Patent Office Application Number 23811901 Application Date 26.05.2023 Inventors
MAKABE KOKI et al.
1225
Detection and isolation of viable cancer cells mediated by spytag and spycatcher using
conditionally replicative adenovirus and magnetic microbeads
Sadegh Goli…Kayhan Azadmanesh. Scientific Reports volume 15, Article number: 11243 (2025)
MATERIALS
Development of a versatile and high-loading capacity yeast surface assembly system via SpyC/SpyT
conjugation
Ke Xu…Guimin Zhang. Process Biochemistry 12 April 2025
Hydrogels with prestressed tensegrity structures
Bin Xue…Yi Cao. Nature Communications volume 16, Article number: 3637
(2025)
MATERIALS
METHODS AND MOLECULAR CONSTRUCTS FOR INCORPORATING MOLECULES
INTO ELECTRICAL CIRCUITS
Patent WO/2025/080785 Publication Date 17.04.2025 Applicants ARIZONA
BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY
[US]/[US] RECOGNITION ANALYTIX, INC. [US]/[US]
MATERIALS
POLYPEPTIDES AND PEPTIDE TAGS CAPABLE OF SPONTANEOUS ISOPEPTIDE
BOND FORMATION AT LOW TEMPERATURE AND LOW PH AND USES
THEREOF
WO/2025/074091, Publication Date 10.04.2025 Inventors: READING, Eamonn;
HAMMERSCHMID, Dietmar; HOWARTH, Mark; KEEBLE, Anthony
SYSTEMS OF SINGLE-CELL LABELING AND METHODS OF USING THE SAME
Patent Application Number 18902306 Publication Date 03.04.2025 Inventor
Amelia ESCOLANO
IMMUN
GENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS
Patent WO/2025/076409 Publication Date 10.04.2025 In
ventors FISCHBACH, Michael, A. et al.
IMMUN
EPITOPE PEPTIDE AND ANTIBODY FOR TREATING HBV INFECTION AND RELATED DISEASES
Patent 18832696 Publication Date 27.03.2025 Applicants XIAMEN UNIVERSITY, YANG SHENG TANG COMPANY, LTD.
IMMUN
BIOENGINEERING MICROBIAL ENCAPSULIN NANO-PARTICLES AS EFFICACIOUS NANOMEDICINE FOR NUCLEIC ACIDS
Patent WO/2025/068517 Publication Date 03.04.2025 Inventors HELALAT, Seyed Hossein; SUN, Yi
IMMUN
Destabilising Effect of Class B CpG Adjuvants on Different Proteins and Vaccine Candidates
Kawkab Kanjo…Raghavan Varadarajan. Vaccines 2025, 13(4), 395
IMMUN
A customized multienzyme cascade immobilization system for efficiently biosynthesizing allitol
Xuanzhen Ma…Hui-Min Qin. Food Bioscience 9 April 2025, 106578
ENZ
Multiphasic protein condensation governed by shape and valency
Vikas Pandey…Hidetoshi Urakubo. Cell Reports 7 April 2025, 115504
MATERIALS
AMINO ACID BINDING AGENTS AND THEIR USES
Patent WO/2025/064836 Publication Date 27.03.2025 Applicants GLYPHIC
BIOTECHNOLOGIES, INC. [US]/[US]
SEQUENCING
Continuous Protein Sensing Using Fast-Dissociating Antibody Fragments in
Competition-Based Biosensing by Particle Motion
Claire M. S. Michielsen…Menno W. J. Prins. ACS Sensors 2025 Mar
Enhancement of Lycopene Biosynthesis Using Self-Assembled Multi-Enzymic
Protein Cages
Yulong Zhou…Bing Tian. Microorganisms 2025, 13(4), 747
ENZ
Extracellular Bacterial Production of DNA Hydrogels–Toward Engineered Living
Materials
Philipp Gaspers…Christof M. Niemeyer. Small 2025 Mar
MATERIALS
A combined adjuvant and ferritin nanocage based mucosal vaccine against
Streptococcus pneumoniae induces protective immune responses in a murine model
Tien Duc Nguyen…Joon Haeng Rhee. Nature Communications volume 16, Article number: 2871 (2025)
IMMUN
VERSATILE IMMUNOGENIC MODULES AND NANOPARTICLES FOR TICK VACCINES
WO/2025/057109 Publication Date 20.03.2025 Inventors CORREA, Agustin et al.
IMMUN
Mechanically weak and highly dynamic state of mechanosensitive titin Ig domains induced by proline is
omerization
Yukai Wang…Shimin Le. Nature Communications volume 16, Article number: 2771 (2025)
MATERIALS
Controlled Enzyme Cargo Loading in Engineered Bacterial Microcompartment Shells
Nicholas M. Tefft…Michaela A. TerAvest. Biochemistry 2025 Mar
MATERIALS
ENZ
The SpyBLI cell-free pipeline for the rapid quantification of binding kinetics from crude samples
Olga Predeina…Mark R. Howarth, Pietro Sormanni. bioRxiv 2025 March
Functional and structural profiling of circulation via genetically encoded modular fluorescent probes.
Marta Vittani…Hajime Hirase. bioRxiv 2025 Mar
IMAGING
PRODUCTION AND PURIFICATION OF COVALENTLY SURFACE MODIFIED ADENO-ASSOCIATED VIRUS
Patent WO/2025/054526 Publication Date 13.03.2025 REGENERON PHARMACEUTICALS, INC. [US]/[US]
IMMUN
NOVEL HEPATITIS C VIRUS (HCV) IMMUNOGENS AND RELATED USES
Patent WO/2025/054380 Publication Date 13.03.2025 Inventors HE, Linling et al.
IMMUN
SYSTEMS AND METHODS FOR GENERATING MULTIVALENT MOSAIC HLA NANOPARTICLES FOR PERSONALIZED
IMMUNOTHERAPY APPLICATIONS
Patent WO/2025/049742 Publication Date 06.03.2025 SGOURAKIS, Nikolas et al.
IMMU
N
1200
A BIVALENT POLYPEPTIDE SCAFFOLD AND USES THEREOF
Patent WO/2025/046229 Publication Date 06.03.2025 HOWARTH, Mark and DRISCOLL, Claudia
IMMUN
OMEGA-guided DNA polymerases enable random mutagenesis in a tunable window
Li-Hua Liu…Ao Jiang. Trends Biotech 2025 Mar
ENZ
INJECTABLE HYDROGEL FOR SUSTAINED CO-DELIVERY OF AN ANTIGEN AND AN ADJUVANT, AND USES
THEREOF
Patent United States of America Application Number 18826093 Szu-Wen Wang et al.
MATERIALS
IMMUN
ALPHA-HELICAL PROTEIN NANOFIBRILS
Patent WO/2025/046122 Publication Date 06.03.2025 REMAUT, Han et al.
MATERIALS
CATENATED VAR2CSA RECOMBINANT PROTEIN, PREPARATION METHOD THEREFOR, AND USE THEREOF
Patent USA Application Number 18727302 Application Date 09.06.2022 CAS LAMVAC (GUANGZHOU)
BIOMEDICAL TECHNOLOGY
IMMUN
Surface display of eugenol oxidase and dioxygenase complex as a sustainable biocatalyst for efficient
bioconversion of lignin-derived 4-n-propylguaiacol to vanillin
Yongqing Tian…Jing Wo. Microbial Cell Factories volume 24, Article number: 54 (2025)
ENZ
Reversible peptide tagging system to regulate enzyme activity
Yao Chen…Ling Jiang. Cell Reports Physical Sciences 4 March 2025, 102462
ENZ
Preparation of multimeric peptide-MHC with SpyCatcher modules for antigen-specific T cell detection
Xiangyao Wang…Si Liu. Sensors and Actuators B 430, 1 May 2025, 137342
IMMUN
Construction of a Cofactor Self-Sufficient Enzyme Cascade System Coupled with Microenvironmental
Engineering for Efficient Biosynthesis of Tetrahydrofolate and Its Derivative of L-5-Methyltetrahydrofolate
Ziting Yan…Kequan Chen. Catalysts 2025, 15(3), 235
ENZ
Intermolecular Misfolding Captured in Parallelly Organized Titin
Jiacheng Zuo…Hongbin Li. Journal of the American Chemical Society Vol 147/Issue 6 February 2, 2025
MATERIALS
Simplified MS2 phage-like particle production including a novel maturation protein internal fusion affinity tag
Enos C. Kline…Barry R. Lutz. Biotechnology & Biotechnological Equipment Volume 39, 2025 - Issue 1
MATERIALS
Development and Efficacy Evaluation of a Novel Nanoparticle-Based Hemagglutination Inhibition Assay for Serological Studies of Porcine Epidemic Diarrhea
Virus
Fengyan Liang…Yifei Lang. Vet. Sci. 2025, 12(2), 101
IMMUN
Tetravalent Virus-like Particles Engineered To Display Envelope Domain IIIs of Four Dengue Serotypes in
Silkworm as Vaccine Candidates
Krishna Raja…Enoch Y. Park. Biomacromolecules February 3, 2025
IMMUN
In vivo targeted gene delivery using Adenovirus-antibody molecular glue conjugates
Paul J. Rice-Boucher…Zhi Hong Lu. bioRxiv 2025 Feb
IMMUN
FETCH enables fluorescent labeling of membrane proteins in vivo with spatiotemporal control in Drosophila
Kevin D. Rostam…Richard S. Mann. bioRxiv 2025 Feb
IMAGING
The Power of Three: Dynactin associates with three dyneins under load for greater force production
Lu Rao…Arne Gennerich. bioRxiv 2025 Jan
ENZ
Design and characterization of HIV-1 vaccine candidates to elicit antibodies targeting multiple epitopes
Harry B. Gristick…Pamela J. Bjorkman. bioRxiv 2025 Jan
IMMUN
LIFETIME ALPHA-HEMOLYSIN NANOPORES
US Patent Application Number 18798279 Publication Date 30.01.2025 Applicants Roche Sequencing Solutions,
Inc.
SEQUENCING
DESIGN OF IMMUNOGENS THAT PREFERENTIALLY INTERACT WITH B CELL RECEPTORS CONTAINING COMPLEMENTARY DETERMINING REGION LOOPS OF
SPECIFIC COMPOSITION
Patent WO/2025/029745 Publication Date 06.02.2025 Inventors AZOITEI, Mihai
IMMUN
Engineering high-activity crosslinked enzyme aggregates via SpyCatcher/SpyTag-mediated self-assembly
Xueliang Ma…Lili Jia. International Journal of Biological Macromolecules 295 (2025) 139591
MATERIALS
ENZ
Resolving native GABAA receptor structures from the human brain
Jia Zhou…Ryan E. Hibbs. Nature 2025 Jan
DIRECTLY FUNCTIONALIZED ELECTROCHMICAL TRANSISTEORS, AND CONVECTION DRIVEN ULTRA-RAPID DETECTION OF
BIOMARKERS USING TRANSISTORS
Patent Application Number 18711844 Publication Date 23.01.2025 Inventors Sahika Inal et al.
MATERIALS
AFFINITY PURIFICATION, PROXIMITY-BASED SORTASE LIGATION, AND DETECTION OF PROTEINS WITH PRECURSOR PEPTIDES
AND B1 PROTEINS FROM LASSO PEPTIDE BIOSYNTHESIS SYSTEMS
Patent Application Number 18716935 Publication Date 23.01.2025 Applicants UNIVERSITY OF PENNSYLVANIA AlphaThera
LLC Inventors Andrew TSOURKAS et al.
GENE THERAPY DELIVERY COMPOSITIONS AND METHODS OF USE THEREOF
Patent Application Number 18775975 Publication Date 23.01.2025 Inventors Logan Collins et al.
In Situ Bioconjugation of Synthetic Peptides onto Universal Chimeric Antigen Receptor T Cells for Targeted Cancer
Immunotherapies
Ian I. Cardle…Drew L. Sellers. ACS Nano 2025 Jan
IMMUN
1175
Programmable Scaffold-Mediated Assembly Regulation Tool for Dynamic Control of a Multienzyme Biocatalyst
Mengkai Hu…Zhiming Rao. ACS Catalysis 2025 Jan
ENZ
Designed mosaic nanoparticles enhance cross-reactive immune responses in mice
Eric Wang…Arup K. Chakraborty. Cell 2025 Jan
IMMUN
Programing Green Light-Responsive Hydrogels: from Photo-Weakening to
Photo-unresponsiveness and Photo-Strengthening
Saskia Frank, Seraphine Wegner. Chemistry 14 January 2025
MATERIALS
Designing a microbial factory suited for plant chloroplast-derived enzymes to efficiently and green synthesize natural products: capsanthin and capsorubin
as examples
Huibin Chen…Zhen Liu. Metabolic Engineering 16 January 2025
ENZ
Ferritin nanoparticles significantly enhance the immune response to the
African swine fever virus p34 protein
Rong Zhang…Haixue Zheng. International Journal of Pharmaceutics 16 January
2025
IMMUN
SPATIAL PROXIMITY ASSAY
Patent WO/2025/012402 Publication Date 16.01.2025 Inventors HINNAH,
Konstantin, WILHELM, Jonas, JOHNSSON, Kai
Optimising CAR-T cell sensitivity by engineering matched extracellular sizes
between CAR/antigen and CD2/CD58 adhesion complexes
Jake Burton…Omer Dushek. bioRxiv 2025 Jan
IMMUN
Nanoparticle Vaccine Triggers Interferon-Gamma Production and Confers Protective Immunity against Porcine Reproductive and Respiratory Syndrome
Virus
Yangyang Sun…Ping Jiang. ACS Nano 2025 Jan
IMMUN
MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous sam
ples
Yasuhiro Arimura…Hironori Funabiki. bioRxiv 2025 Jan
MATERIALS
Hidden route of protein damage through oxygen-confined photooxidation
Seoyoon Kim…Duyoung Min. Nature Communications volume 15, Article number: 10873 (2024).
MATERIALS
Development of a Tick-Borne Encephalitis Virus Nanoparticle Vaccine Utilizing Envelope Dimer
Bingjie Wang, Haiyan Zhao. bioRxiv 2024 Nov
IMMUN
Adaptive multi-epitope targeting and avidity-enhanced nanobody platform for ultrapotent, durable antiviral
therapy
Yufei Xiang…Yi Shi. Cell 2024 Nov
In situ forming and self-crosslinkable protein hydrogels for localized cancer therapy and topical wound healing
Soomin Eom…Sebyung Kang. J Cont Rel 2025 Feb
MATERIALS
CONJUGATED MOLECULES
Patent WO/2024/256843 Publication Date 19.12.2024 Applicants VALINK THERAPEUTICS LTD [GB]/[GB]
METHODS FOR PURIFYING FILLED ADENO-ASSOCIATED VIRUS CAPSIDS
Patent WO/2024/263705 Publication Date 26.12.2024 REGENERON PHARMACEUTICALS, INC. [US]/[US]
Preparation and immunogenicity evaluation of ferritin nanoparticles conjugated with African swine fever virus
p30 protein
Yue Zhang…Haixue Zheng. Sheng Wu Gong Cheng Xue Bao 2024 Dec 25;40(12):4509-4520.
IMMUN
NOVEL BINDERS TARGETING THE MULTI-DRUG RESISTANT PATHOGEN ACINETOBACTER BAUMANNII
Patent WO/2024/261344 Publication Date 26.12.2024 Inventors VAN DER HENST, Charles et al.
METHOD FOR SCREENING A MOLECULE FOR BINDING TO A PROTEIN OF INTEREST
Patent WO/2024/256374 Publication Date 19.12.2024 Inventors GILLINGHAM, Dennis
Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-Based Sortase A-Mediated Ligation of T‑Cell Epitopes
Aru Z. Wang…Joke M. M. den Haan. Bioconj Chem 2024 Dec
IMMUN
Hierarchical design of pseudosymmetric protein nanocages
Quinton M. Dowling…Neil P. King. Nature 2024 Dec
MATERIALS
SpyFixer enables efficient site-specific immobilization for protein-protein interaction analysis and antibody purification
Ya Xiang…Xiaofeng Yang. International Journal of Biological Macromolecules 287, January 2025, 138548
MATERIALS
Clickable, Thermally Responsive Hydrogels Enabled by Recombinant Spider Silk Protein and Spy Chemistry for Sustained
Neurotrophin Delivery
Yue Li…Fei Sun. Adv Mat 2024 Dec
MATERIALS
Modular functionalization of cellular nanodiscs enables targeted delivery of chemotherapeutics into tumors
Ilkoo Noh…Liangfang Zhang. J Cont Release 2025 Feb
MATERIALS
Delivery of dendritic cells targeting 3M2e-HA2 nanoparticles with a CpG adjuvant via lysosomal escape of Sa
lmonella enhances
protection against H9N2 avian influenza virus
Futing Jia…Yanlong Jiang. Poultry Science 2025
IMMUN
Development of a self-assembled dual-enzyme co-display platform on the surface of the natural “chitosan beads” of yeast
spores
Jiawen Bai…Zijie Li. International Journal of Biological Macromolecules 286, January 2025, 138308
MATERIALS
ENZ
1150
EPITOPE PEPTIDE AND ANTIBODY FOR TREATING HBV INFECTION AND RELATED DISEASES
European Patent Office Application Number 23746324 Publication Date 04.12.2024
Inventors LUO WENXIN et al.
IMMUN
Construction of Chitinase Complexes Using Self-Assembly Systems for Efficient Hydrolysis of Chitin
Zhewei Shen…Chenggang Xu. ACS Synbio 2024 Nov
ENZ
Modular Tunable α-Helical Peptide Hydrogels for Neuronal Cells
D. Arne Scott…Derek N. Woolfson. Adv Funct Mat 2024 Nov
MATERIALS
Remodelling of Rea1 linker domain drives the removal of assembly factors from pre-ribosomal particles
Johan Busselez…Helgo Schmidt. Nature Communications volume 15, Article number: 10309 (2024)
MagIC-Cryo-EM: Structural determination on magnetic beads for scarce macromolecules in heterogeneous samples
Yasuhiro Arimura…Hironori Funabiki. eLife 2024 Nov
MATERIALS
MULTIPLEXED PROFILING OF RNA AND DNA MODIFICATIONS
Patent United States of America Publication Date 21.11.2024 ALIDA BIOSCIENCES INC.
ANTI-VIRUS MOIETY IMMOBILISED IN A MATRIX
Patent United States of America Application Number 18690098 Publication Date 14.11.2024 SAMATVA RESEARCH
CORPORATION
MATERIALS
N-TERMINAL MODIFIER AGENTS AND BINDERS FOR TREATING AND ANALYZING PEPTIDES
Patent United States of America Publication Date 14.11.2024 Applicants Encodia, Inc.
S
EQUENCING
Towards Precision Biocatalysis - Leveraging Inline NMR for Autonomous Experimentation in Flow Reactors
Felix Ott…Christof M. Niemeyer. Chemistry-Methods 2024 Nov
MATERIALS
ENZ
Modular Display of Plasmodium yoelii Circumsporozoite Surface Protein and Merozoite Surface Protein-1 on Norovirus-like
Particles
Jirayu Boonyakida…Enoch Y. Park. Bioconj Chem 2024 Nov
IMMUN
Tuning architectural organization of eukaryotic P450 system to boost bioproduction in Escherichia coli
Yikui Li…Ren Wang. Nature Communications volume 15, Article number: 10009 (2024)
ENZ
The Photocleavable Protein PhoCl-Based Dynamic Hydrogels
Jingqi Lei…Hongbin Li. ACS Biomat Sci 2024 Nov
MATERIALS
Mechanically Tunable, Compostable, Healable and Scalable Engineered Living Materials
Avinash Manjula-Basavanna…Neel S. Joshi. Nature Communications volume 15, Article number: 9179 (2024)
MATERIALS
SPYCATCHER ANALOGS AND USES THEREOF
Patent WO/2024/231728 Publication Date 14.11.2024 BIO-RAD ABD SEROTEC GMBH [DE]/[DE]
PLASMONIC NANOANTENNA AND USE OF SAME IN SINGLE MOLECULE SEQUENCING
Patent WO/2024/229524 Publication Date 14.11.2024 NEWSOUTH INNOVATIONS PTY LIMITED [AU]/[AU]
MATERIALS
SEQUENCING
METHOD FOR DETECTING INTERACTIONS
Patent WO/2024/231680 Publication Date 14.11.2024 Inventors DUSHEK, Omer et al.
VIRAL ANTIGEN DISPLAY COMPOSITIONS AND METHODS
Patent United States of America Publication Date 07.11.2024 Alon M. Herschhorn
IMMUN
Engineering the Mechanical Stability of a Therapeutic Complex between Affibody and Programmed Death-Ligand 1 by Anchor
Point Selection
Byeongseon Yang…Michael A. Nash. ACS Nano 2024 Nov
IMMUN
MATERIALS
A Versatile Method to Create Antibody/Split-Enzyme Complexes and Its Application to a Rapid, Homogeneous, and Universal
Electrochemical Immunosensing System
Yuka Tobita…Ryutaro Asano. Adv Sensor Res 2024 Oct
ENZ
VP8 Mosaic Nanoparticles Elicit Cross-Neutralizing Immune Responses and Provide Protection Against H
eterotypic Rotavirus
Challenge in Mice
Feibo Song…Ningshao Xia. ACS Nano 2024 Nov
IMMUN
Rationally designed multimeric nanovaccines using icosahedral DNA origami for display of SARS-CoV-2
receptor binding domain
Qingqing Feng…Xiao Zhao. Nat Comm 2024 Nov
IMMUN
MATERIALS
Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-
Based Sortase A-Mediated Ligation of T-Cell Epitopes
Aru Z. Wang…Joke M. M. den Haan. Bioconj Chem 2024 Nov
IMMUN
ANTI-HUMAN M-CADHERIN (CDH15) ANTIBODIES, CONJUGATES, AND USES THEREOF FOR DELIVERY OF
GENETIC PAYLOADS TO MUSCLE CELLS
Patent WO/2024/229105 Publication Date 07.11.2024 REGENERON PHARMACEUTICALS, INC. [US]/[US]
Design of a Genetically Programmable and Customizable Protein Scaffolding System for the
Hierarchical Assembly of Robust, Functional Macroscale Materials
Ruijie Zhang…Claudia Schmidt-Dannert. ACS Syn Biol 2024 Oct
MATERIALS
Engineered Outer Membrane Vesicles as Nanosized Immune Cell Engagers for Enhanced Solid Tumor Immunotherapy
Jianan Sun…Xiaobao Bi. ACS Nano 2024 Oct
IMMUN
1125
Light-Based Juxtacrine Signaling Between Synthetic Cells
Hossein Moghimianavval, Kyle J. Loi, Sung-Won Hwang, Yashar Bashirzadeh, Allen P. Liu. Small Science 2024 Oct
MATERIALS
CD11A TAGE COMPOSITIONS AND USES THEREOF
Patent WO/2024/226822 Publication Date 31.10.2024 SPOTLIGHT THERAPEUTICS [US]/[US]
In-Situ Structure and Topography of AMPA Receptor Scaffolding Complexes Visualized by CryoET
Richard G. Held…Axel T. Brunger. bioRxiv 2024 Oct
MATERIALS
CAPSID ENGINEERED ADENO-ASSOCIATED VIRUSES
Patent WO/2024/220714 Publication Date 24.10.2024 Inventors SCHMIDT, Daniel et al.
Magnetic protein aggregates generated by supramolecular assembly of ferritin cages - a modular strategy for
the immobilization of enzymes
Gizem Olcucu…Ulrich Krauss. Front Bioeng 2024 Oct
MATERIALS
The liquid lectin array detects compositional glycocalyx differences using multivalent DNA-encoded lectins on
phage
Guilherme M. Lima…Ratmir Derda. Cell Chem Biol 2024 Oct
MATERIALS
Controlled enzyme cargo loading in engineered bacterial microcompartment shells
Nicholas M Tefft…Michaela A TerAvest. bioRxiv 2024 Oct
MATERIALS
ENZ
MODULAR RE-TARGETING OF RHABDOVIRAL (G) GLYCOPROTEINS FROM THEIR NATURAL RECEPTORS
Patent WO/2024/216223 Publication Date 17.10.2024 VYRIAD [US]/[US]
IMMUN
Developing Porous Protein Cage Nanoparticles as Cargo-Loadable and Ligand-Disp
layable Modular Delivery Nanoplatforms
Soomin Eom…Sebyung Kang. ACS Applied Materials & Interfaces 2024 Oct
MATERIALS
Transient CAR T cells with specificity to oncofetal glycosaminoglycans in solid
tumors
Nastaran Khazamipour…Mads Daugaard. EMBO Mol Med 2024 Oct
IMMUN
Experimental VLP vaccine displaying a furin antigen elicits production of
autoantibodies and is well tolerated in mice
Vili Lampinen…Vesa Hytönen. Nanoscale Advances 2024
IMMUN
Coupling of Spectrin Repeat Modules for the Assembly of Nanorods and
Presentation of Protein Domains
Klemen Mezgec…Roman Jerala. ACS Nano 2024
MATERIALS
Folds from fold: Exploring topological isoforms of a single-domain protein
Zhiyu Qu…Wen-Bin Zhang. PNAS 2024 121 (43) e2407355121
MATERIALS
Construction of bispecific antibodies by specific pairing between the heavy chain and the light chain using removable SpyCatcher/SnoopCatcher units
Jyunna Yoshida…Koki Makabe. Journal of Biological Engineering volume 18, Article number: 57 (2024)
IMMUN
Loop Grafting Improves Neuraminidase Protein Vaccine Production
Pramila Rijal, Leiyan Wei, Guido C Paesen, David I Stuart, Mark R Howarth, Kuan-Ying A Huang, Thomas A Bowden, Alain RM Townsend. bioRxiv 2024 Oct
IMMUN
Plug and play virus-like particles for the generation of anti-toxin antibodies
Rebecca J. Edge…Stuart Ainsworth. Toxicon X 2024 September
IMMUN
Development of a Two-Component Nanoparticle Vaccine Displaying an HIV-1
Envelope Glycoprotein that Elicits Tier 2 Neutralising Antibodies.
Malebo, K…Chapman, R. Vaccines 2024 Oct
IMMUN
Development and Characterization of A Novel SpyTagged Modular Nanobody as A
Detection Platform for CD22-Positive Cells
Amirhosein Maali…Zahra Sharifzadeh. Cell J 2024 Oct 7;26(8):487-495.
IMMUN
A Modular Bacteriophage T4 Nanoparticle Platform Enables Rapid Design of
Completely Protective Multivalent Mucosal Dual Vaccine Against COVID-19 and
Flu
Jingen Zhu…Venigalla B. Rao. bioRxiv 2024 Oct
IMMUN
Modular Nano-Antigen Display Platform for Pigs Induces Potent Immune Responses
Yilan Chen…Gaiping Zhang. ACS Nano 2024 Oct
IMMUN
Modulation of SpyCatcher Ligation Kinetics by SpyTag Thioamide Substitution
Kristen E. Fiore…E. James Petersson. bioRxiv 2024 Oct
A Versatile Magnetic Nanoplatform for Plug-and-Play Functionalization: Genetically Programmable Cargo Loading to
Bacterial Magnetosomes by SpyCatcher
“Click Biology”
Frank Mickoleit…Dirk Schüler. ACS Nano 2024 Oct
MATERIALS
Preparation of Bio-Orthogonal Self-Cross-Linked Arabinose Isomerase for Enzymatic Synthesis of ʟ-Ribulose
Houtian Luo…Li Qiao. Chemistry 03 October 2024
ENZ
Single-molecule force spectroscopy reveals intra- and intermolecular interactions of Caenorhabditis elegans HMP-1
during mechanotransduction
Shimin Le…Jie Yan. PNAS 2024 Jul
MATERIALS
A Spy Chemistry-Based Method for Purification of Proteins with Authentic N-Termini
by Xiaofeng Yang…Zhanglin Lin. Catalysts 2024, 14(9), 651
1100
Targeted Delivery of BCL-2 siRNA Using Modified Ferritin Nanocarriers for Antitumor Therapy
Li-Miao Qin…Yuqing Wu. ACS Applied Nano Materials September 26, 2024
IMMUN
Proximity-Unlocked Luminescence by Sequential Enzymatic Reactions from Antibody and Antibody/Aptamer
(PULSERAA): A Platform for Detection and Visualization of Virus-Containing Spots
Daimei Miura…Ryutaro Asano. Advanced Science 2024 Sept
METHODS FOR IN VIVO EDITING OF B CELLS
Patent WO/2024/196669 Publication Date 26.09.2024 WALKING FISH THERAPEUTICS, INC. [US]/[US], WASHINGTON
UNIVERSITY [US]/[US]
IMMUN
ARTIFICIAL COMPLEX FOR TETHERING CHROMATIDS OR CHROMOSOMES
Patent WO/2024/194344 Publication Date 26.09.2024 Inventors SCHUH, Melina et al.
Repurposing Copper(II)/THPTA as A Bioorthogonal Catalyst for Thiazolidine Bond Cleavage
Chengyun Ma…Xiaobao Bi. Advanced Science19 September 2024
Ferritin nanoparticle-based Nipah virus glycoprotein vaccines elicit potent protective immune responses in mic
e and hamsters
Shaohong Chen…Sandra Chiu. Virologica Sinica 16 September 2024
IMMUN
Dynamic allostery drives autocrine and paracrine TGF-β signaling
Mingliang Jin…Yifan Cheng. Cell 2024 Sept
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Michael I. Barton…Philip Anton van der Merwe. Communications Biology volume 7, Article number: 1138 (2024)
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Patent 18270436 Application Date 31.12.2021 Inventors Peter D. Kwong et al.
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COMPOSITIONS AND METHODS FOR PRODUCING GLYCOCONJUGATE POLYPEPTIDES HAVING ISOPEPTIDE BONDS
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SEQUENTIAL ENCODING METHODS AND RELATED KITS
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Genetically surface-modified Escherichia coli outer membrane vesicles targeting MUC1 antigen in cancer cells
Sedthawut Laotee, Wanatchaporn Arunmanee. Biotechnology Reports Volume 44, December 2024, e00854
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An Antibiotic-Degrading Engineered Biofilm Platform to Combat Environmental Antibiotic Resistance
Gökçe Özkul…Şafak Şeker. ACS Biomaterials Science & Engineering September 3, 2024
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DNA-Directed Activation of Photocatalytic Labeling at Cell–Cell Contact Sites
Xu Zhou…Jeffrey D. Martell. ACS Chemical Biology September 3, 2024
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CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic cell death of acute myeloid leukemia, prolonging survival in mouse
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Elena Ethel…Ali Salanti. Nature Communications volume 15, Article number: 7553 (2024)
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Directional co-immobilization of artificial multimeric-enzyme complexes as a robust biocatalyst for biosynthesis curcumin glucosides and regeneration of
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Stepping dynamics of dynein characterized by MINFLUX
Joseph Slivka…Ahmet Yildiz. bioRxiv 2024
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A.C. Greenman…S.P. Harris. bioRxiv 2024
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Design of a Soluble Multivalent Notch Agonist
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The role of protein shape in multiphasic separation within condensates
Vikas Pandey…Hidetoshi Urakubo. bioRxiv 2024
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Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals
Lizett Ortiz de Ora…Travis J Wiles. Nature Microbiology (2025)
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Nonlinear compliance of NompC gating spring and its implication in mechanotransduction
Yukun Wang…Yongli Zhang. bioRxiv 2024
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SubtiToolKit - a bioengineering kit for Bacillus subtilis and Gram-positive bacteria
Joaquin Caro-Astorga…Tom Ellis. bioRxiv 2024
Interplay of kinetochores and catalysts drives rapid assembly of the mitotic checkpoint complex
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Conditional CAR T cells with specificity to oncofetal glycosaminoglycans in solid tumors
Nastaran Khazamipour…Mads Daugaard. bioRxiv 2024
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Engineering the Mechanical Stability of a Therapeutic Affibody/PD-L1 Complex by Anchor Point Selection
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CHIMERIC PROTEINS AND THEIR USE AS AN ANTIGEN DETECTING SYSTEM
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Endogenous capsid-forming protein ARC for self-assembling nanoparticle vaccines
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IMMUN
Mosaic sarbecovirus nanoparticles elicit cross-reactive responses in pre-vaccinated animals
Alexander A. Cohen…Pamela J. Bjorkman. Cell 2024 Aug
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Directional co-immobilization of artificial multimeric-enzyme complexes as a robust biocatalyst for biosynthesis curcumin glucosides and regeneration of
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A SARS-CoV-2 peptide antigen purified from bacteria and displayed in a high-density repetitive manner on a virus-like particle could generate anti-SARS-CoV-
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Feroza Begum…Upasana Ray. BBRC Aug 2024
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CTC-derived pancreatic cancer models serve as research tools and are suitable for precision medicine approaches
Jiajia Tang…Christopher Heeschen. Cell Reports Medicine August 19, 2024
A Click-Type Enzymatic Method for Antigen-Adjuvant Conjugation
Yange Sun…Li Zhu. Small Methods 23 August 2024
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TREATMENT OF MUSCLE RELATED DISORDERS WITH ANTI-HUMAN CACNG1 ANTIBODIES
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COMPOSITIONS AND METHODS FOR CONTROLLED MRNA TRANSLATION AND STABILITY
US patent 18392928 Publication Date 08.08.2024 Applicants TRUSTEES OF BOSTON UNIVERSITY
Site-specific tethering nanobodies on recombinant adeno-associated virus vectors for retarg
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Influenza virus strains expressing SARS-CoV-2 receptor binding domain protein confer
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Reinforcing thermostability and pH robustness of exo-inulinase facilitated by
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Virus-like particles displaying the mature C-terminal domain of filamentous hemagglutinin are immunogenic and protective against Bordetella pertussis
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Controlled labelling of tracer antibodies for time-resolved fluorescence-based immunoassays
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EPITOPE-SCAFFOLD IMMUNOGENS FOR PANCORONAVIRUS VACCINES
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Probing the Topological Effects on Stability Enhancement and Therapeutic Performance of Protein Bioconjugates: Tadpole,
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Yajie Liu…Wen-Bin Zhang. Adv Health Mat 2024 Aug
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Sustainable Spinning of Artificial Spider Silk Fibers with Excellent Toughness and Inherent Potential for Functionalization
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Enhancing the stress resistance of nitrile hydratase from Rhodococcus ruber
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Engineering a Self-Assembled Protein Cage for Targeted Dual Functionalization
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VCP/p97-associated proteins are binders and debranching enzymes of K48–K63-
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Sven M. Lange…Yogesh Kulathu. Nature Structural & Molecular Biology (2024)
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Orchestrated Codelivery of Peptide Antigen and Adjuvant to Antigen-Presenting
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Induction of neutralising antibodies against conserved rhinovirus capsid protein VP4 depends on presenting VP4 in a virus-like
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Genetically Decorating Microbial Surface Curli Fiber with Biocatalytic Properties
Qingxia Wang…Jinyong Yan. ACS Sustainable Chem. Eng. 2024, Jul
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COMPOSITIONS AND METHODS FOR CONTROLLED MRNA TRANSLATION AND STABI
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Genetically Programmed Temperature-Responsive Barnacle-Derived Protein with an Enhanced Adhesio
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Yuanxing Shi…Jinyong Yan. ACS Appl. Bio Mater. 2024
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Engineering Mesoscale T Cell Receptor Clustering by Plug-and-Play Nanotools
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BROADLY NEUTRALIZING ANTIBODY-TEMPLATED DIVALENT IMMUNOGEN VACCINES
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COMPOSITIONS AND METHODS FOR FIBROBLAST GROWTH FACTOR RECEPTOR 3-MEDIATED DELIVERY
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Cu(II)/THPTA-Mediated Thiazolidine Deprotection for Living Phages and Cell Surfaces Labeling
Chengyun Ma…Xiaobao Bi. ChemRxiv 07 June 2024
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Development of an improved blood-stage malaria vaccine targeting the essential RH5-CyRPA-RIPR invasion complex
Barnabas G. Williams…Simon J. Draper. Nature Communications volume 15, Article number: 4857 (2024)
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AlbuCatcher for Long-Acting Therapeutics
Ji Hyun Rho…Inchan Kwon. ACS Omega 2024, 9, 21, 22990–23000
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Single immunization of non-adjuvanted recombinant TTFC-mi3 nanoparticle vaccine elicited a rapid and potent protective immunity against tetanus
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Microgels with Immobilized Glycosyltransferases for Enzymatic Glycan Synthesis
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Enhancing the Stress Resistance of Nitrile Hydratase from Rhodococcus ruber via
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Design of a genetically programmable and customizable protein scaffolding system for the
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Ruijie Zhang…Claudia Schmidt- Dannert. bioRxiv 2024 May
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Mosaic and cocktail capsid-virus-like particle vaccines for induction of antibodies against
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Ilary Riedmiller…Louise Turner. bioRxiv 2024 April
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Genetically modifying the protein matrix of macroscopic living materials to control their
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Esther M. Jimenez…Caroline M. Ajo-Franklin. bioRxiv 2024 May
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Development and Characterization of Recombinant ADP-Ribose Binding Reagents that Allow
Simultaneous Detection of Mono and Poly ADP-Ribose
Shu-Ping Chiu…W. Lee Kraus. bioRxiv 2024 May
Preserving ester-linked modifications reveals glutamate and aspartate mono-ADP-ribosylation by PARP1 and its reversal by PARG
Edoardo José Longarini & Ivan Matić. Nature Communications volume 15, Article number: 4239 (2024)
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TALIN-BASED MECHANOSENSORY HYDROGEL
Patent WO/2024/100399 Publication Date 16.05.2024 Applicants UNIVERSITY OF KENT [GB]/[GB] Inventors HISCOCK, Jennifer, GOULT, Ben
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Reengineering of an Artificial Protein Cage for Efficient Packaging of Active Enzymes
Yusuke Azuma…Jonathan G. Heddle. Small 2024 May
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Comparative analysis of folding and unfolding dynamics and free-energy landscapes in homologous cold shock proteins with variable thermal stabilities
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Engineering Pickering Emulsion with Cell Surface-Displayed Esterase Est7 for Specific and Efficient Synthesis of EPA Monoglyceride
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Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses
Chuanyu Liu…George F. Gao. Cell Reports 2024 May
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MODIFIED COVALENTLY-LINKED PILI AND RECOMBINANT BACTERIA COMPRISING THE SAME
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UNIVERSAL ADJUVANT FOR NASAL, ORAL, AND INTRAMUSCULAR DELIVERY OF VACCINES
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SELF-ADJUVANTING MULTI-PROTEIN COMPLEXES FOR MODULAR VACCINE PRODUCTION
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Customizable Click Biochemistry Strategy for the Design and Preparation of Glucagon-like Peptide-1 Conjugates and
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Ligand-dependent folding and unfolding dynamics and free energy landscapes of acylphosphatase
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Construction of Switch Modules for CAR-T Cell Treatment Using a Site-Specific Conjugation System
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SpyTag Peptide with Alkoxyl Aspartic Acids for pH-Dependent Activation of the SpyCatcher/Tag System
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Catalytic Synthesis of (S)-CHBE by Directional Coupling and Immobilization of Carbonyl Reductase and Glucose
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BUOYANCY ACTIVATED CELL SORTING AND SCALABLE PROTEIN PURIFICATION WITH ENGINEERED GAS VESICLES
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POLYPEPTIDE FUSIONS OR CONJUGATES FOR GENE EDITING
Patent WO/2024/086596 Publication Date 25.04.2024 4M GENOMICS INC.
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SYNTHETIC INTERMEDIATES FOR UNIVERSAL CHIMERIC ANTIGEN RECEPTOR IMMUNE CELL
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Patent WO/2024/081824 Publication Date 18.04.2024 Applicants UNIVERSITY OF WASHINGTON
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Detoxifying Cyanides Using Cyanase Enzyme Complexes Composed of Carbonic Anhydrase via
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Habin Sun…Jeong Eun Hyeon. J. Agric. Food Chem. 2024, 72, 10, 5318–5324
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Antigen-functionalized turnip mosaic virus nanoparticles increase antibody sensing in saliva. A case
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DIRECTED IN VIVO AFFINITY MATURATION OF ANTIBODIES
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Overcoming Protein Orientation Mismatch Enables Efficient Nanoscale Light-Driven ATP Production
Andrea Marco Amati…Christoph von Ballmoos. ACS Synth. Biol. April 3, 2024
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Precision Engineering the Co-Immobilization of Enzymes for Cascade Biocatalysis
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AN ENZYMATIC SYSTEM FOR PRECISE CELL TARGETING
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AFFINITY CAPTURING AND DIRECTLY DETERMINING STRUCTURES OF PROTEINS AND OTHER MATERIALS ON
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Construction of a versatile fusion protein for targeted therapy and immunotherapy
Xiu-Song Huang…Cai-Wen Duan. Protein Science 19 March 2024
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Rational Design of Spontaneous Self-Cyclization Enzymes In Vivo and In Vitro with Improved Thermal Tolerance and
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Intranasal delivery of Salmonella OMVs decorated with Chlamydia trachomatis antigens induces specific local and
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SpyMask enables combinatorial assembly of bispecific binders
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Molecular density-accelerated binding-site maturation underlies CENP-T-dependent kinetochore assembly
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Rational structure-guided design of a blood stage malaria vaccine immunogen
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Thomas E. Harrison…Matthew K. Higgins. bioRxiv 2024
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Designed mosaic nanoparticles enhance cross-reactive immune responses in mice
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Architecture and flexibility of native kinetochores revealed by structural studies
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A cVLP-Based Vaccine Displaying Full-Length PCSK9 Elicits a Higher Reduction in
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NANOPARTICLE-DERIVED VACCINES AGAINST POXVIRUSES, AND METHODS FOR
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HIGH THROUGHPUT PEPTIDE IDENTIFICATION USING CONJUGATED BINDERS AND KINETIC ENCODING
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Mosaic sarbecovirus vaccination elicits cross-reactive responses in pre-immunized animals
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Development and Immunological Evaluation of a Multiantigen Thermostable Nanovaccine Adjuvanted with
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Irreversible light-activated SpyLigation mediates split-protein assembly in 4D
Brizzia G. Munoz-Robles & Cole A. DeForest. Nature Protocols 2024 Jan
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OptoREACT: Optogenetic Receptor Activation on Nonengineered Human T Cells
Anja Armbruster…Maximilian Hörner. ACS Synth. Biol. 2024 Feb
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High-Level Secretory Production of Recombinant E2-Spy Antigen Protein via Combined Strategy in Pichia
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Flow-Induced Microfluidic Assembly for Advanced Biocatalysis Materials
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Nanoengineering Carboxysome Shells for Protein Cages with Programmable Cargo Targeting
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Active Template Synthesis of Protein [n]Catenanes Using Engineered Peptide–Peptide Ligation Tools
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Development of plug-and-deliverable intracellular protein delivery platforms based on botulinum neurotoxin
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VIRAL PARTICLES RETARGETED TO TRANSFERRIN RECEPTOR 1
Patent WO/2024/026494 Publication Date 01.02.2024 REGENERON PHARMACEUTICALS, INC. [US]/[US]
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De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
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Spontaneous and site-specific immobilization of PNGase F via spy chemistry
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Cryo-EM analysis on magnetic beads for scarce macromolecules in heterogeneous samples
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Engineering multivalent Fc display for FcγR blockade
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Discovery and engineering of the antibody response against a prominent skin commensal
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Enhancing humoral and mucosal immune response of PED vaccine candidate by fusing S1 protein to
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Photoactivatable Nanobody Conjugate Dimerizer Temporally Resolves Tiam1-Rac1 Signaling Axis
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Affinity-assisted covalent self-assembly of PduQ-SpyTag and Nox-SpyCatcher to construct multi-enzyme complexes on the surface of magnetic microsphere
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Hossein Moghimianavval…Allen P Liu. bioRxiv 2024 Jan
Reengineering of an artificial protein cage for efficient packaging of active enzymes
Yusuke Azuma…Jonathan G. Heddle. bioRxiv 2023 Dec
ENZ
Enhancing immune responses of ESC-based TAA cancer vaccines with a novel OMV delivery system
Meiling Jin…Jian-Dong Huang. Journal of Nanobiotechnology volume 22, Article number: 15 (2024)
IMMUN
Hidden route of protein damage through confined oxygen gas
Seoyoon Kim…Duyoung Min. bioRxiv 2024 Jan
MATERIALS
Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved
Anti-Malarial
Antibodies
Lloyd D W King…Mark Howarth, Sumi Biswas, Simon J Draper. Cell Reports Medicine Volume 5, Issue 7, 16 July
2024, 101654 and bioRxiv 2024 Jan
IMMUN
Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and
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Jason Gorman…Peter D. Kwong. Nature Communications volume 15, Article number: 285 (2024)
IMMUN
KARI NANOPARTICLE
Patent WO/2024/006532 Publication Date 04.01.2024 OLMEDILLAS, Eduardo et al.
Extraordinary Titer and Broad Anti-SARS-CoV-2 Neutralization Induced by Stabilized RBD Nanoparticles from Strain
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Z. Wang…S. Wang. Vaccines 2024
IMMUN
SpyDirect: A Novel Biofunctionalization Method for High Stability and Longevity of Electronic
Biosensors
Keying Guo…Sahika Inal. Advanced Science 31 December 2023
MATERIALS
Display of PETase on the Cell Surface of Escherichia coli Using the Anchor Protein PgsA
Takuma Yamashita…Hiroyasu Ogino. Applied Biochemistry and Biotechnology Jan 2024
ENZ
Lipid nanodisc scaffold and size alter the structure of a pentameric ligand-gated ion channel
Vikram Dalal…Wayland W. L. Cheng. Nature Communications volume 15, Article number: 25
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Molecular Engineering of a Spider Silk and Mussel Foot Hybrid Protein Gives a Strong and Tough
Biomimetic Adhesive
Yin Yin…Markus B. Linder. Advanced Materials Interfaces 02 January 2024
MATERIALS
METHODS FOR SPORE DISPLAY
Patent WO/2023/245018 Publication Date 21.12.2023 Inventors NICKS, Trevor et al.
MATERIALS
IMMUN
The SpyCatcher-SpyTag interaction mediates tunable anti-tumor cytotoxicity of NK cells.
Guo C…Zhu W. Mol Immunol. 2023 Dec 20;165:11-18.
IMMUN
Ligand-Mediated Mechanical Enhancement in Protein Complexes at Nano- and Macro-Scale
Samuel Kim…Minkyu Kim. ACS Appl. Mater. Interfaces 2023
MATERIALS
De novo Semi-synthetic Platform for Monitoring Protein degradation in Live Cells
Mahdi Hasan…Ashraf Brik. Chembiochem 2023 Nov 30:e202300731.
Protein cage nanoparticle-based NK cell-engaging nanodrones (NKeNDs) effectively recruit NK cells to target tumor sites
and suppress tumor growth
Seong Guk Park…Sebyung Kang. Nanotoday 2024 Feb
IMMUN
Engineered immunogens to elicit antibodies against conserved coronavirus epitopes
A. Brenda Kapingidza…Mihai L. Azoitei. Nature Communications volume 14, Article number: 7897 (2023)
IMMUN
METHODS AND COMPOSITIONS FOR DETERMINING THE ANTIGEN SPECIFICITY OF T CELLS
Patent WO/2023/235761 Publication Date 07.12.2023 Inventors HACOHEN, Nir BAKALAR, Matthew
IMMUN
UNIVERSAL ADJUVANT FOR NASAL, ORAL, AND INTRAMUSCULAR DELIVERY OF VACCINES
Patent WO/2023/230241 Publication Date 30.11.2023 DESIGN-ZYME LLC [US]/[US]
IMMUN
Encapsulation of AAV into protein vault nanoparticles as a novel solution to gene therapy's
neutralizing antibody problem
Logan Thrasher Collins…David Curiel. bioRxiv 2023 Nov
IMMUN
MATERIALS
Accelerating the design of pili-enabled living materials using an integrative technological
workflow
Yuanyuan Huang…Chao Zhong. Nature Chemical Biology (2023)
MATERIALS
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein
immunogens
Shamim Ahmed…Alon Herschhorn. npj Vaccines volume 8, Article number: 181 (2023)
IMMUN
Free Energy Landscape of Type III Fibronectin Domain with Identified Intermediate State and
Hierarchical Symmetry
Hao Sun…Hu Chen. Phys. Rev. Lett. 131, 218402 – Published 22 November 2023
MATERIALS
Dimer stabilization by SpyTag/SpyCatcher coupling of the reductase domains of a chimeric P450 BM3 monooxygenase from
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Arabella Essert, Kathrin Castiglione. ChemBioChem 2023 Nov
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A candidate nanoparticle vaccine comprised of multiple epitopes of the African swine fever virus elicits a robust
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Jinxing Song…Gaiping Zhang. Journal of Nanobiotechnology volume 21, Article number: 424 (2023)
IMMUN
VECTORS AND METHODS FOR IN VIVO ANTIBODY PRODUCTION
Patent WO/2023/220603 Publication Date 16.11.2023 REGENERON PHARMACEUTICALS, INC. [US]/[US]
IMMUN
Study on the properties of a dual-system-based protein scaffold for orthogonal self-assembly
Meng Zhang…Jun Zhao. International Journal of Biological Macromolecules16 November 2023, 127946
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Development of a Tag/Catcher-mediated capsid virus-like particle vaccine presenting the conserved Neisseria gonorrhoeae
SliC antigen that blocks human lysozyme
Fabian G Martinez…Aleksandra E Sikora. Infect Immun 2023 Nov 2:e0024523.
IMMUN
Protein nanoscaffold enables programmable nanobody-luciferase immunoassembly for sensitive and simultaneous detection of aflatoxin B1 and
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Shaowen Wu…Shijuan Yan. J Hazard Mater 2023 Oct 5:462:132701.
ENZ
A novel protein purification scheme based on salt inducible self-assembling peptides
Guang Zeng…Zhanglin Lin. Microbial Cell Factories volume 22, Article number: 224 (2023)
A BACTERIOPHAGE-BASED, NEEDLE AND ADJUVANT-FREE, MUCOSAL COVID-19 VACCINE
Patent WO/2023/209556 Publication Date 02.11.2023 Inventors RAO, Venigalla B. et al.
IMMUN
VARIANTS OF THE GAIN DOMAIN OF ADHESION G PROTEIN-COUPLED RECEPTORS
Patent WO/2023/213993 Publication Date 09.11.2023 Inventors MARFOGLIA, Matthieu et al.
METHOD FOR BIOSYNTHESIS OF PROTEIN HETEROCATENANE
Patent United States of America Application Number 17999377 Publication Date 02.11.2023
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A modular approach to enhancing cell membrane-coated nanoparticle functionality using genetic
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Nishta Krishnan…Liangfang Zhang. Nature Nanotechnology (2023) Oct
IMMUN
A nanoparticle vaccine displaying the ookinete PSOP25 antigen elicits transmission-blocking
antibody response against Plasmodium berghei
Guixiang Yao…Yaming Cao. Parasites & Vectors volume 16, Article number: 403 (2023)
IMMUN
Molecular imaging of bacterial outer membrane vesicles based on bacterial surface display
Dávid Szöllősi…Krisztián Szigeti. Scientific Reports volume 13, Article number: 18752 (2023)
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Patent Application Number 18301228 Publication Date 19.10.2023 Applicants David Curiel et al.
IMMUN
MODIFIED VIRAL PARTICLES FOR GENE THERAPY
US patent Application Date 11.05.2023 Publication Date 26.10.2023 Inventors Paul Alexander HEPPENSTALL
IMMUN
LONG LIFETIME ALPHA-HEMOLYSIN NANOPORES
US patent Application Number 18171969 Publication Date 19.10.2023 Applicants Roche Sequencing
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Engineered Reversible Inhibition of SpyCatcher Reactivity Enables Rapid Generation of Bispecific Antibodies
Christian Hentrich…Francisco Ylera. Nature Communications volume 15, Article number: 5939 (2024)
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IMMUN
Mechanical disengagement of the cohesin ring
Martina Richeldi…Maxim I. Molodtsov. Nature Structural & Molecular Biology (2023) Oct
MATERIALS
Thermostable T Cell Multiepitope Nanoparticle Antigens Inducing Potent Immune Responses against the
Swine Fever Virus
Lidan Sun…Zeliang Chen. ACS Infect. Dis. 2023, Oct
IMMUN
Toward Minimal Transcription–Translation Machinery
Ting Wang and Yuan Lu. ACS Synth. Biol. 2023 Oct
ENZ
An Antibiotic Degrading Engineered Living Material Platform to Combat Environmental Antibiotic Resistance
Gokce Ozkul…Ozgur Safak Seker. bioRxiv 2023 Oct
MATERIALS
HIGH THROUGHPUT PEPTIDE IDENTIFICATION USING CONJUGATED BINDERS AND KINETIC ENCODING
Patent WO/2023/201365 Publication Date 19.10.2023 ENCODIA, INC. [US]/[US]
SEQUENCING
Engineering of an Optogenetic T Cell Receptor Compatible with Fluorescence-Based Readouts
Vincent Idstein…Wolfgang W. Schamel. ACS Synth. Biol. 2023 Oct
IMMUN
Biological Applications of Synthetic Binders Isolated from a Conceptually New Adhiron Library
Claudia D’Ercole…Ario de Marco. Biomolecules 2023, 13(10), 1533
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
JL Watson…E Derivery. Cell Volume 186, Issue 21, 12 October 2023, Pages 4710-4727.e35
Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs
Chaoyu Fu…Jie Yan. Nano Lett. 2023 Oct
MATERIALS
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here
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